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Aspartate aminotransferase (EC 2.6.1.1, AST)，formerly called Glutamic Oxalacetic Transaminase (GOT), is present in both cytoplasm and mitochondria of cells，belonging to the transaminase family, which catalyze the conversion of amino acids and α-oxoglutarate by transfer of amino groups. AST is commonly found in various human tissues. The heart muscle is found to have the most activity of the enzyme, secondly in the brain, liver, gastric mucosa, skeletal muscle and kidneys. The serum AST present low activity in the healthy human body, but when these tissues injury or damage, AST is released into
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